| Age of onset |
| Usually after age 40 |
| Commonly affected joints |
| Cervical and lumbar spine |
| First carpometacarpal joint |
| Proximal interphalangeal joint |
| Distal interphalangeal joint |
| Hip |
| Knee |
| Subtalar joint |
| First metatarsophalangeal joint |
| Uncommonly affected joints |
| Shoulder |
| Wrist |
| Elbow |
| Metacarpophalangeal joint |
| Symptoms |
| Pain without significant swelling or other inflammatory characteristics |
| Stiffness, if present, worse after effort; may be described as evening stiffness |
| Findings on physical examination |
| Crepitus |
| Bony enlargement |
| Decreased range of motion |
| Malalignment |
| Tenderness to palpation |
| Synovial fluid analysis |
| Clear fluid |
| WBC <2000/mm3 |
| Normal viscosity |
| Radiographic features |
| Joint space narrowing |
| Subchondral sclerosis |
| Marginal osteophytes |
| Subchondral cysts |
| Patterns of presentation |
| Monoarticular in young adult |
| Pauciarticular, large-joint in middle age |
| Polyarticular generalized |
| Rapidly progressive |
| Secondary to trauma, congenital abnormality, or systemic disease |
| Prognosis |
| Variable, generally slowly progressive |