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Nikolsky sign
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Panels A and B show the Nikolsky sign elicited by rubbing the skin at the periphery of an existing lesion. Panels C and D show the Nikolsky sign elicited by rubbing the normal-appearing skin distant from the lesions. These two methods appear to have different sensitivity and specificity for pemphigus.
Reproduced with permission from: Uzun S, Durdu M. The specificity and sensitivity of Nikolsky sign in the diagnosis of pemphigus. J Am Acad Dermatol 2006; 54:411. Copyright © 2006 The American Academy of Dermatology.
Graphic 78514 Version 3.0