Different eye manifestations of herpes simplex virus-1 infection. Panel A: Corneal epithelial disease with damaged epithelial cells observed as "dendrites" after staining with dyes. Panel B: Corneal stromal disease or "disciform keratitis;" this reflects severe damage to infected epithelial cells, producing stromal edema with corneal clouding. Panel C: Necrotizing stromal disease in which infiltration of inflammatory cells and neovascularization results in destruction of the cornea, glaucoma, and dense scarring. Panel D: Keratouveitis in which mononuclear cell clusters, termed "keratic precipitates," can be seen in the corneal epithelium.